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Static Method: out = Theoph ()

Pharmacokinetics of Theophylline


An experiment on the pharmacokinetics of theophylline.



Categorical identifying the subject on whom the observation was made. The ordering is by increasing maximum concentration of theophylline observed.


Weight of the subject (kg).


Dose of theophylline administerred orally to the subject (mg/kg).


Time since drug administration when the sample was drawn (hr).


Theophylline concentration in the sample (mg/L).


Boeckmann, Sheiner and Beal (1994) report data from a study by Dr. Robert Upton of the kinetics of the anti-asthmatic drug theophylline. Twelve subjects were given oral doses of theophylline then serum concentrations were measured at 11 time points over the next 25 hours.

These data are analyzed in Davidian and Giltinan (1995) and Pinheiro and Bates (2000) using a two-compartment open pharmacokinetic model, for which a self-starting model function, SSfol, is available.


The data are given in Box & Jenkins (1976). Obtained from the Time Series Data Library at


Boeckmann, A. J., Sheiner, L. B. and Beal, S. L. (1994). NONMEM Users Guide: Part V. NONMEM Project Group, University of California, San Francisco.

Davidian, M. and Giltinan, D. M. (1995). Nonlinear Models for Repeated Measurement Data. London: Chapman & Hall. (section 5.5, p. 145 and section 6.6, p. 176)

Pinheiro, J. C. and Bates, D. M. (2000). Mixed-effects Models in S and S-PLUS. New York: Springer. (Appendix A.29)


t = octave.dataset.Theoph;

# TODO: Coplot
# TODO: Yet another linear model to port to Octave

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